What is Hydroxypropyl-β-Cyclodextrin？

Hydroxypropyl-β-Cyclodextrin (HP-β-CD) is a modified form of beta-cyclodextrin, a cyclic oligosaccharide derived from starch. This versatile compound is characterized by its toroidal structure, which features a hydrophilic exterior and a lipophilic interior cavity. HP-β-CD's unique molecular architecture allows it to form inclusion complexes with various hydrophobic molecules, enhancing their solubility and stability. This remarkable property has made HP-β-CD an invaluable tool in pharmaceutical formulations, cosmetics, and food technology. Its ability to encapsulate and protect active ingredients while improving their bioavailability has revolutionized drug delivery systems and product development across multiple industries.

What Does Hydroxypropyl-β-Cyclodextrin Do?

Hydroxypropyl-β-Cyclodextrin can form inclusion complexes with a variety of compounds, thereby improving the water solubility, stability, antioxidant and anti-photolysis capabilities of the guest molecules, or achieving sustained release and stereo separation effects.

The introduction of hydroxypropyl breaks the intramolecular cyclic hydrogen bonds of beta-cyclodextrin, while maintaining the cyclodextrin cavity and overcoming the main disadvantage of poor water solubility of beta-cyclodextrin. Pharmaceutical grade Hydroxypropyl-β-Cyclodextrin is an ideal injection solubilizer and drug excipient.

Benefits of Hydroxypropyl-β-Cyclodextrin

• Increase drug solubility and improve bioavailability:

Due to the high hydrophilicity of Hydroxypropyl-β-Cyclodextrin, it is more conducive to the rapid dissolution of drugs in the gastrointestinal tract, increasing its solubility in water, further improving the bioavailability of drugs, enhancing efficacy, and reducing dosage. 

• Increase drug solubility and improve bioavailability:

After the drug is encapsulated by Hydroxypropyl-β-Cyclodextrin, it is enclosed in the inner cavity of Hydroxypropyl-β-Cyclodextrin, which can effectively reduce photolysis, oxidation and thermal damage, and is conducive to maintaining drug stability. The rate of drug overproduction increased by nearly 4 times.

• Adjust drug release rate:

For commonly taken drugs, the inclusion complexation of Hydroxypropyl-β-Cyclodextrin can achieve four types of controlled release, namely immediate release, delayed release (time-controlled release), extended release and controlled release.

• Enhance the corneal permeability of drugs:

Hydroxypropyl-β-Cyclodextrin can enhance the corneal permeability of drugs. For example, hydroxypropyl beta-cyclodextrin can increase the corneal permeability of pilocarpine nitrate by nearly 4 times.

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